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	Provedor de dados Genet. Mol. Biol. (1) Autor Ahnert,Peter (1) Burkhardt,Jana (1) Kirsten,Holger (1) Quente,Elfi (1) Wolfram,Grit (1) Palavra-chave Candidate gene (1) Gene expression (1) Gene polymorphism (1) QTL (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Differential allelic expression of IL13 and CSF2 genes associated with asthma Genet. Mol. Biol. Burkhardt,Jana; Kirsten,Holger; Wolfram,Grit; Quente,Elfi; Ahnert,Peter. An important area of genetic research is the identification of functional mechanisms in polymorphisms associated with diseases. A highly relevant functional mechanism is the influence of polymorphisms on gene expression levels (differential allelic expression, DAE). The coding single nucleotide polymorphisms (SNPs) CSF2rs25882 and IL13rs20541 have been associated with asthma. In this work, we investigated whether the mRNA expression levels of CSF2 or IL13 were correlated with these SNPs. Samples were analyzed by mass spectrometry-based quantification of gene expression. Both SNPs influenced gene expression levels (CSF2rs25882: p overall = 0.008 and pDAE samples = 0.00006; IL13rs20541: p overall = 0.059 and pDAE samples = 0.036). For CSF2, the expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: Candidate gene; Gene expression; Gene polymorphism; QTL. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400004 Registros recuperados: 1 Primeira ... 1 ... Última

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